New drugs take aim at one of cancer’s deadliest mutations
A form of pancreatic cancer (pictured) is often caused by mutations in the KRAS protein.Credit: PJD/SPL Armed with sophisticated chemistry and fresh approaches to drug design, researchers are closing in on innovative strategies to undermine a cancer-causing mutant protein once considered ‘undruggable’. Mutations in a protein called KRAS fuel some of the most lethal cancers….