Population-scale repeat expansions elucidate disease risk and brain atrophy

Sample preparation and exome sequencing Exome sequencing was performed at the Regeneron Genetics Center using a custom automated sample preparation approach (Supplementary Information 9). Samples from MAYO-CLINIC and part of the CNCD (n = 25,580) cohorts were captured with Twist Comprehensive Exome probes and the remaining cohorts were captured with IDT xGen v1 and sequenced using the Illumina…

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