Flexible learning relies on integrating sensory and contextual information to adjust behavioral output in different environments. The anterolateral motor cortex (ALM) is a frontal area critical for action selection in rodents. We found that inputs … Source link
Natural systems use metal ions to form ordered structures that regulate biological processes, inspiring the rational design of nanotherapeutics. The cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of interferon genes (cGAS-… Source link
Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how short, specific RNAs solubilize TDP-43. These short RNAs … Source link
Strongly correlated materials feature multiple electronic orbitals, which are crucial to accurately understanding their many-body properties. In such multiband models, quantum interference can lead to flat energy bands with large degeneracy that gives … Source link
Editors’ selections from the current scientific literature Source link
STING agonist nanoparticles trigger potent antitumor immunity in mice and rabbits Source link
Federal grant cancellations, restrictions on immigration for foreign scientists, and attempts to cut the budgets of science funding agencies by 60%—the past 18 months have been tumultuous for American science. Even after Congress restored the budgets, … Source link
Water infrastructure in conflict zones is vulnerable to deliberate kinetic strikes as well as the silent failure of maintenance and supply chains severed by war. When these systems collapse, the consequences cascade through public health and food security, exacerbating the vulnerabilities of regions already facing extreme climate stress. For example, recent attacks targeted desalination plants…
In March, attacks on water infrastructure in Qeshm Island, Iran, and in Bahrain (1) drew attention to how quickly disruptions can threaten potable water supply in the Middle East. Across the Persian Gulf region and Israel, desalination supplies a dominant share of municipal drinking water. Centralized desalination plants enable economic growth and urbanization in some…