Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how short, specific RNAs solubilize TDP-43. These short RNAs …
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Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration | Science
