RESEARCH BRIEFINGS 08 April 2026 The abundance of viral DNA was measured in DNA sequenced from blood and saliva samples in biobanks, revealing strong correlations with age, sex and dozens of genetic variants. Genetic analyses indicate that a high abundance of latent Epstein–Barr virus is a causal risk factor for a blood cancer called Hodgkin’s…
Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01132-4 Nature staff discuss some of the week’s top science news. Source link
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These authors contributed equally: Andrea Viale, Piergiorgio Pettazzoni Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA Andrea Viale, Piergiorgio Pettazzoni, Haoqiang Ying, Nora Sánchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Florian Muller, Simona Colla, Luigi Nezi, Giannicola Genovese, Angela K. Deem, Avnish Kapoor, Wantong Yao, Y. Alan Wang & Giulio F. Draetta Department of Molecular and Cellular Oncology, The University of Texas MD Anderson…
Sample preparation and exome sequencing Exome sequencing was performed at the Regeneron Genetics Center using a custom automated sample preparation approach (Supplementary Information 9). Samples from MAYO-CLINIC and part of the CNCD (n = 25,580) cohorts were captured with Twist Comprehensive Exome probes and the remaining cohorts were captured with IDT xGen v1 and sequenced using the Illumina…
Center for Neuroscience and Artificial Intelligence, Baylor College of Medicine, Houston, TX, USA Eric Y. Wang, Paul G. Fahey, Zhuokun Ding, Stelios Papadopoulos, Kayla Ponder, Andersen Chang, Taliah Muhammad, Saumil Patel, Zhiwei Ding, Dat Tran, Jiakun Fu, Katrin Franke, Jacob Reimer, Xaq Pitkow, Fabian H. Sinz & Andreas S. Tolias Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA Eric Y. Wang, Paul G. Fahey, Zhuokun Ding, Stelios Papadopoulos, Kayla Ponder, Andersen Chang, Taliah Muhammad, Saumil Patel, Zhiwei…
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Ethics statement De-identified tissue samples were collected at Stanford University School of Medicine from elective termination of pregnancy procedures with informed consent for the research use of tissues in observance of relevant legal and institutional ethical regulations. No demographic information was collected. Consent was obtained by the medical team. The relevant tissue sample processing and…
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Destination vector cloning We built a specific custom destination vector for efficient Golden Gate cloning of enhancer fragments. This included the reporter gene cassette NanoLuc-Ires-mNGreen-pA, downstream of a mCMV promoter. A bacterial suicide ccdB cassette spanning the enhancer position enabled assembly of a single enhancer for selection and efficient cloning. This was based on the…