Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer

Lap-NET1 clinical trial Study design and participants Lap-NET1 is a multicentric, prospective, single-arm phase 1b trial. This study included a safety lead-in phase to confirm the recommended dose of NP137 in combination with mFOLFIRINOX (ClinicalTrials.gov identifier: NCT05546853). Patients were enrolled and treated between March 2023 and June 2024 at nine sites in France. Eligible patients…

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Senate GOP fears shutdown streak

Welcome to The Hill’s Business & Economy newsletter {beacon} Business & Economy Business & Economy   The Big Story Republicans fear string of shutdowns under Trump Senate Republicans who are scrambling to end the two-month shutdown of the Department of Homeland Security (DHS) fear that Democrats will trigger an even bigger government shutdown in October……

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Human cooperation undergoes constant breakdown and repair

Sabin, N., Klinowski, D. & Reed-Tsochas, F. Nature https://doi.org/10.1038/s41586-026-10380-3 (2026). Article  Google Scholar  Acemoglu, D. & Robinson, J. A. The Narrow Corridor: States, Societies, and the Fate of Liberty (Penguin, 2019). Google Scholar  Dekel, E., Ely, J. C. & Yilankaya, O. Rev. Econ. Stud. 74, 685–704 (2007). Google Scholar  Akçay, E., Van Cleve, J., Feldman,…

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    Suburban Propane CEO: Producing Record Levels Domestically

    Suburban Propane President and CEO Michael Stivala joins Bloomberg Businessweek Daily to discuss the company’s current supply and demand outlook as the Iran war weighs on commodities and consumer costs across the board. Stivala says the company’s robust domestic supply is keeping inventory levels elevated at a record high. He speaks with Carol Massar and…

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