Prime assembly with linear DNA donors enables large genomic insertions

Suzuki, K. et al. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature 540, 144–149 (2016). Article  ADS  CAS  PubMed  PubMed Central  Google Scholar  Yamamoto, Y. & Gerbi, S. A. Making ends meet: targeted integration of DNA fragments by genome editing. Chromosoma 127, 405–420 (2018). Article  CAS  PubMed  PubMed Central  Google Scholar  Anzalone,…

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Evolutionary characterization of lung cancer metastasis

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK Sonya Hessey, Abigail Bunkum, Ariana Huebner, Kerstin Haase, Kristiana Grigoriadis, Cristina Naceur-Lombardelli, Wing Kin Liu, Charlotte Grieco, Carlos Martínez-Ruiz, Piotr Pawlik, Olivia Lucas, Corentin Richard, Kerstin Thol, Takahiro Karasaki, Sophia Ward, Foteini Athanasopoulou, Monica Sivakumar, Selvaraju Veeriah, Antonia Toncheva, Paulina Prymas, Martin D. Forster, Siow Ming Lee, Crispin T. Hiley, Alexander A. Azizi, Lydia Y. Liu, Nicolai J. Birkbak, Karen Grimes, Clare Puttick, Despoina Karagianni, Francisco Gimeno-Valiente, Georgia Moth, Ieva Usaite, Iva…

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Postprandial lipid metabolism durably enhances T cell immunity

Ethics and study approval All experiments detailed in this manuscript were approved by the University of Pittsburgh Institutional Animal Care and Use Committee (20077737 and 23073380). The use of retroviral vectors was approved by the Institutional Biosafety Committee. Research involving human participants was approved by the institutional review board (21090049). Animals C57BL/6J inbred mice were…

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Engineered blood clots stop bleeding in seconds

Jiang, S. et al. Nature https://doi.org/10.1038/s41586-026-10412-y (2026). Article  Google Scholar  Guo, B., Dong, R., Liang, Y. & Li, M. Nature Rev. Chem. 5, 773–791 (2021). Article  PubMed  Google Scholar  Peshkova, A. D. et al. Blood Adv. 9, 3418–3428 (2025). Article  PubMed  Google Scholar  Garyfallogiannis, K. et al. Acta Biomater. 159, 49–62 (2023). Article  PubMed  Google…

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Author Correction: Broadly stable atmospheric CO2 and CH4 levels over the past 3 million years

College of Earth, Ocean, and Atmospheric Sciences, Oregon State University, Corvallis, OR, USA Julia Marks-Peterson, Christo Buizert, Michael Kalk, Demetria Eves, Jenna Epifanio & Edward Brook Department of Geology and Geophysics, Woods Hole Oceanographic Institution, Woods Hole, MA, USA Sarah Shackleton Department of Geosciences, Princeton University, Princeton, NJ, USA Sarah Shackleton, John Higgins, Valens Hishamunda, Austin Carter & Michael Bender Scripps Institution of Oceanography, University of…

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In the flesh

Getting pulled meatside is always disgusting, but it’s worse during an emergency shutdown. In the verses, my sleek form adapts seamlessly to my surroundings: looks hot, smells great, tastes delicious. This sack of flesh is all dusting, wrinkling, sagging, spotting, fermenting, fugging meatness. I reek like my Faecal Management System has malfunctioned, my stomach acid…

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Do octopus brains work like humans’ — or is there another way to be smart?

Three hearts; blue blood; no skeleton; arms like tongues. These are just some of the alien features of octopuses, squid and cuttlefish — members of the cephalopod family. The outlandish list continues. Cephalopod skin can taste chemicals, sense light and change colour and texture rapidly. In many species, the sucker-covered arms can even regenerate. Cephalopods…

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