Study sponsorship, authorizations and ethics This study was an investigator initiated trial sponsored by Gustave Roussy and covered by a Biomedical Research Promoter Civil Liability insurance contract (contract 124.895) in accordance with the provisions of the French law (Decree 2006-477 of 26 April 2006 and Article L.1121-10 of the French Public Health Code). This study…
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CLINICAL BRIEFINGS 29 April 2026 In people with advanced skin cancer, injecting low doses of an anticancer immunotherapy directly into tumours, rather than administering high doses intravenously, reduced severe immune toxicity while preserving antitumour efficacy. Pre-existing antitumour immunity predicted clinical benefit most strongly, and profiling fresh tissue provided response biomarkers faster than conventional diagnostics did….
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This skeleton from the early medieval site of Altheim belonged to a woman whose ancestors migrated from northern Europe several generations earlier.Credit: SAM/Harbeck After the collapse of the Roman Empire, its northern frontier became a melting pot of soldiers, farmers and ‘barbarians’, finds an analysis of ancient genomes from hundreds of burials in southern Germany….
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SAMOSA from E14 mouse ES cells We compiled a large compendium of SAMOSA data from wild-type E14 mouse ES cells, comprising both newly generated datasets and published datasets from our laboratory, including: (1) our study on the function of ISWI-family remodelling complexes3; (2) samples prepared with our SMRT-Tag protocol, which uses a transposase-based strategy for…
No sample size calculations were performed before the study. Sample sizes were determined to be acceptable based on the magnitude of effect size from previous or preliminary experiments. Experiments were not randomized. Investigators were not blinded to group allocation during data collection. Mice Mice were housed and bred under specific pathogen-free conditions, maintained on a…
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