Monolithic 3D integration of tantalum pentoxide nonlinear photonics

Jung, H. et al. Tantala Kerr nonlinear integrated photonics. Optica 8, 811–817 (2021). Article  ADS  Google Scholar  Desiatov, B., Shams-Ansari, A., Zhang, M., Wang, C. & Lončar, M. Ultra-low-loss integrated visible photonics using thin-film lithium niobate. Optica 6, 380–384 (2019). Article  ADS  CAS  Google Scholar  Wang, C. et al. Ultrahigh-efficiency wavelength conversion in nanophotonic periodically…

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Linear RAG scanning mediates editing of Igκ variable region repertoires

Experimental procedures We did not use statistical methods to predetermine sample size. We also did not randomize experiments. During experiments and outcome assessments, investigators were not blinded to allocation. Mice We purchased wild-type 129SV mice from Taconic Biosciences. We have previously described the generation and characterization of 129SV mice harbouring the Cer/Sis deletion22. Mouse work…

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AI models ‘subliminally’ transmit unsafe behaviours when training other systems

An AI model showed a preference for owls despite never being trained to show such a bias.Credit: Denis Moskvinov/Shutterstock Data generated by artificial-intelligence models can contain subliminal signals that ‘teach’ other large-language models (LLMs) particular traits and biases, suggests a study published in Nature today1. Such biases can be benign — a preference for a…

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Landmark ancient-genome study shows surprise acceleration of human evolution

Some gene variants became consistently more or less frequent over time in ancient human populations — a sign of natural selection. Credit: Denis-Art/Getty The biggest ever study of ancient human DNA shows that human evolution has accelerated over the past 10,000 years. Researchers identified hundreds of gene variants that evolved through natural selection in ancient…

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Mapping convergent regulators of melanoma drug resistance by PerturbFate

Cell culture A375, HEK293T, Sk-Mel-3 and Sk-Mel-24 cell lines were obtained from the American Type Culture Collection. A375 and HEK293T cells were maintained in high-glucose Dulbecco’s modified Eagle’s medium supplemented with L-glutamine, sodium pyruvate (Gibco; 11995065) and 10% fetal bovine serum (FBS) (Sigma-Aldrich; F4135). Sk-Mel-3 cells were maintained in McCoy’s 5A medium (Gibco; 16600082) supplemented…

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Composable neural emulators accelerate thermoelectric generator design

Snyder, G. J. & Ursell, T. S. Thermoelectric efficiency and compatibility. Phys. Rev. Lett. 91, 148301 (2003). Article  PubMed  Google Scholar  Skomedal, G. et al. Design, assembly and characterization of silicide-based thermoelectric modules. Energy Convers. Manage. 110, 13–21 (2016). Article  CAS  Google Scholar  Zhang, Q. et al. Realizing a thermoelectric conversion efficiency of 12% in…

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