Experimental methods Human sample preparation Human samples and clinical data were obtained from patients undergoing either hepatectomy surgery due to a hepatic pathology or a donor hepatectomy for a living donor liver donation (Fig. 1b). In the hepatectomies that were performed due to liver pathologies, a sample was taken at least 5 cm from the closest…
Animals Animal experiments were performed following standard ethical guidelines (European Communities Guidelines on the Care and Use of Laboratory Animals, 86/609/EEC), and were approved by the Veterinary Department of the Canton of Basel-Stadt. C57BL6, PV-cre (The Jackson Laboratory, 008069) mice and PV-cre mice crossed with Ai9(RCL-tdT) mice (The Jackson Laboratory, 007909) in the C57BL6 background…
Over the past nine years, DRUP provided opportunities for off-label treatment to more than 1,600 patients with advanced cancers with no remaining standard therapeutic options. This included a substantial proportion (39.1%) of patients with rare cancers—patients who typically face limited histology-based options and who benefited equally from the precision strategy24. Across patients treated in stage…
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Brainwide fUSI measurements Experiments were conducted in 5 C57/BL6 mice (3 male, 2 female), 13–34 weeks of age. All experimental procedures were conducted according to the UK Animals Scientific Procedures Act (1986). Experiments were performed at University College London, under a Project License released by the Home Office following appropriate ethics review. Surgery Mice were…
Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10504-9 Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements Source link
Min Yu Present address: Department of Stem Cell Biology and Regenerative Medicine, University of Southern California, Los Angeles, CA, USA Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA, USA Nicole Vincent Jordan, Aditya Bardia, Ben S. Wittner, Cyril Benes, Matteo Ligorio, Yu Zheng, Min Yu, Tilak K. Sundaresan, Joseph A. Licausi, Rushil Desai, Ryan M. O’Keefe, Richard Y. Ebright, Myriam Boukhali, Srinjoy Sil, Maristela L. Onozato, Anthony J….
Saturated heterocycles are privileged scaffolds in bioactive molecules.1 Despite the availability of numerous de novo routes to various heterocyclic compounds, accessing diverse heterocycles from a unified, readily available carbocycle would offer a strategic alternative for constructing challenging heterocyclic structures from unconventional precursors.2 Here we report a modular approach that transforms a single cyclic ketone into…