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Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-01212-5 Modelling suggests that the layer beneath the planet’s acidic clouds is comprised of particles from outer space. Source link
Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00910-4 A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction. Source link
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The authors have retracted this article because, upon further analysis, one of the synthetic song pairs used in the female preference test (data in Fig. 3c,d) was shown to be reliable in its ranking of short versus long path length only 35% of the time and a second song pair was reliable only 75% of the time….
Cancer dependency map analysis Genome-wide gene dependency scores were obtained from the Cancer Dependency Map (DepMap) 2024 Q2 CRISPRGeneEffect.csv public data release47. Cell line generation, exogenous expression, siRNA and cell viability assays Cell lines were grown in RPMI 1640 medium supplemented with 10% FCS with the exception of HEK293T cells, which were grown in Dulbecco’s…
RESEARCH BRIEFINGS 15 April 2026 A platform for tracking the changes in gene expression and chromatin accessibility that follow interference with specific genes has been developed. The platform, called PerturbFate, was applied to skin-cancer cells and showed that different genetic perturbations associated with tumour resistance push cells into a shared dedifferentiated state. Source link
Patients This study was approved by the University Medical Centre (UMC) Utrecht ethical committee, carried out in accordance with the ethical guidelines and regulations and all patients provided written informed consent. FFPE specimens for immunohistochemistry and spatial transcriptomics were requested from and provided by the UMC Utrecht pathology department. Patient inclusion for the organoid biobank…
Cloning, protein expression and purification The DNA encoding ThermoCas9 with a C-terminal His6 tag was integrated into the pML-1B vector and expressed in the Escherichia coli NiCo21(DE3) strain. Cells were grown in Luria–Bertani (LB) medium with 0.2% d-(+)-glucose at 37 °C until optical density at 600 nm reached 0.8, at which point addition, isopropyl-β-d-thiogalactopyranoside was added to 0.5 mM…
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