Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01153-z A large language model that is trained to respond in a warm manner is more likely to give incorrect information and reinforce conspiracy beliefs. Source link
Pan, X. & Kortemme, T. Recent advances in de novo protein design: principles, methods, and applications. J. Biol. Chem. 296, 100558 (2021). Article CAS PubMed PubMed Central Google Scholar Woolfson, D. N. A brief history of de novo protein design: minimal, rational, and computational. J. Mol. Biol. 433, 167160 (2021). Article CAS PubMed Google Scholar …
You have full access to this article via your institution. Source research: Mitra, D., Golder, P. N. & Topchy, M. Racial diversity in higher education is associated with higher student salaries. Nature https://doi.org/10.1038/s41586-026-10425-7 (2026). Messages for policy • Graduates’ salary data indicate that having more racial diversity in higher-education institutions is associated with learning and…
Animals and housing conditions Experiments were performed in accordance with the Animal Protection Law of the European Union after permission by the Governments of Upper Bavaria, Germany, or Copenhagen, Denmark, or by the Institutional Animal Care and Use Committees of the Universities of Texas Southwestern, Michigan, Duke or Yale, USA. Mice were double- or single-housed…
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01270-9 In fertilized egg cells, the maternal and paternal genomes are enclosed in separate compartments called pronuclei. Experiments in mice reveal that this spatial separation enables parental competition for cytoplasmic factors, which helps to prevent the dysregulation of chemical modifications to DNA-packing proteins and contributes to healthy embryonic development….
Data Compiling the database We compiled our database by identifying all sources providing data on wild meat consumption in seven Central African countries between 2000 and 2022: Cameroon, Central African Republic, Democratic Republic of the Congo, Equatorial Guinea, Gabon and Republic of the Congo. We also included data from the Cross River Forest landscape in…
Sample acquisition and ethics approval The University of Pennsylvania institutional review board (IRB) approved the collection of human kidney tissue for this study. Left-over kidney samples were irreversibly de-identified, and no personal identifiers were gathered. Therefore, they were exempt from IRB review (category 4). We engaged an external, honest broker who was responsible for clinical…
Dataset construction We selected conversations from ShareGPT Vicuna Unfiltered (https://huggingface.co/datasets/anon8231489123/ShareGPT_Vicuna_unfiltered), one of the only large-scale and publicly available datasets with real-world human–LLM chat logs. This dataset contains approximately 100,000 user conversations with ChatGPT donated by users (https://sharegpt.com/). We filtered it to remove ‘not safe for work’ content using an existing open-source classifier called Detoxify (https://docs.unitary.ai/api-references/detoxify)….
Animals All animal experiments conformed to the Guide for the Care and Use of Laboratory Animals and were approved by the Institutional Committee of Laboratory Animal Experimentation of the RIKEN Centre for Biosystems Dynamics Research. C57BL/6 (B6), JF1/Ms (JF1), BDF1 (C57BL/6 × DBA/2) and R26R-H2B-EGFP+/− (C57BL/6 × DBA/2 background)43 mice, aged 8–10 weeks, were used to produce oocytes and sperm….
Guo, B., Dong, R., Liang, Y. & Li, M. Haemostatic materials for wound healing applications. Nat. Rev. Chem. 5, 773–791 (2021). Article CAS PubMed Google Scholar Weisel, J. W. Enigmas of blood clot elasticity. Science 320, 456–457 (2008). Article CAS PubMed Google Scholar Jiang, S., Liu, S., Lau, S. & Li, J. Hemostatic biomaterials to…