Cell lines HT29 (HTB-38), T84 (CCL-248) and 293T (CRL-3216) cells were originally obtained from the ATCC. HT29-Cas9 cells were generated as previously described21. All cell lines were grown at 37 °C and 5% CO2. HT29 cell lines were propagated in McCoy’s 5A medium, T84 lines in DMEM/F-12 and 293T cells in DMEM; all supplemented with 10%…
KineCond is a code developed to calculate the time-dependent condensation processes of minerals in the solar nebula, which is dominated by hydrogen. It is described in detail in Supplementary Section 3 with several validation tests, and here we give a summarized version. The elements considered in the system are H, He,O, Mg, Si, Fe, Al, Na,…
Lap-NET1 clinical trial Study design and participants Lap-NET1 is a multicentric, prospective, single-arm phase 1b trial. This study included a safety lead-in phase to confirm the recommended dose of NP137 in combination with mFOLFIRINOX (ClinicalTrials.gov identifier: NCT05546853). Patients were enrolled and treated between March 2023 and June 2024 at nine sites in France. Eligible patients…
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Ubiquitin signalling covers a vast realm of protein modifications, yet may still be underestimated due to non-proteinaceous substrates, such as sugars, lipids, and nucleotides1 . The breadth of ubiquitinated non-protein substrates, their abundance, and cellular roles are currently unclear, since current ubiquitinomic and proteomic techniques are blind to non-proteinaceous modifications. We report Non-Protein Ub-clipping (NoPro-clipping) as…
ScFks1 expression and purification ScFks1 was expressed and purified from S. cerevisiae BY4741 fks2 deletion strain18 harbouring the genomic copy of the fks1 gene engineered to have a C-terminal HRV3C protease site, ten amino acid linker, 3× Flag tag, and 10× His-tag. The fks1 gene was modified by homologous recombination by following a standard procedure42. To…
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Nature, Published online: 22 April 2026; doi:10.1038/d41586-026-00810-7 A form of the inflammatory protein caspase-5 is expressed in immature gut cells, where it promotes proliferation and facilitates tissue regeneration. Source link