Isolate genome collection A total of 19,837 publicly available isolate genomes were collected and consisted of the entire data in the Unified Human Gastrointestinal Genome (UHGG) catalogue45 (v.1.0, 10,648 genomes) and 4 large-scale culturomic studies28,46,47,48. Furthermore, a group of 186 isolates from Austrian individuals were newly collected and sequenced. A total of 50 patients undergoing…
Patient recruitment Experiments were conducted according to protocol guidelines approved by the Institutional Review Board for Baylor College of Medicine and Affiliated Hospitals (H-50885 for the Neuropixels recordings and H-18112 for the EMU recordings). All of the recruited patients for the Neuropixels recordings were diagnosed with drug-resistant temporal lobe epilepsy and were scheduled to undergo…
Human subjects All human samples included in this study were collected with informed consent for research use and received approval from the Institutional Review Boards of Yale University School of Medicine and Washington University School of Medicine, in accordance with the principles of the Declaration of Helsinki (2013). These samples, obtained from a total of…
Some proteins (artist’s illustration) are being reclassified in databases as a result of the latest findings.Credit: Christoph Burgstedt/Getty The human genome contains around 20,000 genes that hold instructions for making working proteins, as most genetic databases now indicate. However, some scientists say there might be thousands more ‘dark proteins’ with unknown but potentially important roles…
Nature, Published online: 06 May 2026; doi:10.1038/d41586-026-01480-1 Neuronal recordings taken during surgery reveal that the brain can learn even when unconscious — plus, the electrical test that can determine a cup of coffee’s strength. Source link
Bravyi, S. et al. High-threshold and low-overhead fault-tolerant quantum memory. Nature 627, 778–782 (2024). Article ADS CAS PubMed PubMed Central Google Scholar Xu, Q. et al. Constant-overhead fault-tolerant quantum computation with reconfigurable atom arrays. Nat. Phys. 20, 1084–1090 (2024). Article CAS Google Scholar Goto, H. Many-hypercube codes: high-rate quantum error-correcting codes for high-performance fault-tolerant quantum…
PeptideAtlas database construction and searching The human non-HLA PeptideAtlas 2023-06 build contains 295 ProteomeXchange datasets (PXDs)50 split into 1,172 different experiments that comprise a total of 3.5 billion MS/MS spectra. Sequence database searching was performed using MSFragger51 v.3.7 using search parameters appropriate for each dataset, depending on alkylation, labelling, fragmentation type, instrument, enrichment strategy and more….
Practical quantum computers will require many millions of interacting quantum bits (qubits). This could, in principle, be achieved by using a property of electrons called spin as a qubit. Spin qubits must be located very close together, and the physical challenge of wiring them to the bulky external control hardware has so far limited quantum…
Phylogenetic analysis The amino acid sequence of GeCas12a2 was aligned with other Cas12a2 nuclease sequences15,59 using Clustal Omega60. The alignment was trimmed with ClipKIT61 and used to reconstruct a phylogeny with IQ-TREE v2.0.3 (-m MFP -T 8 -B 1000)62, using a maximum-likelihood approach. The phylogeny included Cas12a orthologues and used Cas12c as an outgroup. Branch…
Samples The active area of MLC1 of 85PST–15PMW was used for STEM. MLC1 of 85PST–15PMW and MLC1 of 90PST–10PMW were used for indirect EC measurements from which efficiency was evaluated and for direct measurements of EC temperature change that were converted to effective temperature change. MLC2 of 85PST–15PMW and MLC2 of 90PST–10PMW were crushed to…